Ontology highlight
ABSTRACT:
SUBMITTER: Berrocal A
PROVIDER: S-EPMC7864633 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Berrocal Augusto A Lammers Nicholas C NC Garcia Hernan G HG Eisen Michael B MB
eLife 20201210
We used live imaging to visualize the transcriptional dynamics of the <i>Drosophila melanogaster even-skipped</i> gene at single-cell and high-temporal resolution as its seven stripe expression pattern forms, and developed tools to characterize and visualize how transcriptional bursting varies over time and space. We find that despite being created by the independent activity of five enhancers, <i>even-skipped</i> stripes are sculpted by the same kinetic phenomena: a coupled increase of burst fr ...[more]