Crystal structure of the human PRPK-TPRKB complex.
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ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC7864929 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Publications
Crystal structure of the human PRPK-TPRKB complex.
Li Jian J Ma Xinli X Banerjee Surajit S Chen Hanyong H Ma Weiya W Bode Ann M AM Dong Zigang Z
Communications biology 20210205 1
Mutations of the p53-related protein kinase (PRPK) and TP53RK-binding protein (TPRKB) cause Galloway-Mowat syndrome (GAMOS) and are found in various human cancers. We have previously shown that small compounds targeting PRPK showed anti-cancer activity against colon and skin cancer. Here we present the 2.53 Å crystal structure of the human PRPK-TPRKB-AMPPNP (adenylyl-imidodiphosphate) complex. The structure reveals details in PRPK-AMPPNP coordination and PRPK-TPRKB interaction. PRPK appears in a ...[more]
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