Ontology highlight
ABSTRACT:
SUBMITTER: Lai TH
PROVIDER: S-EPMC7865263 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20210125 3
The adenosine A<sub>2A</sub> receptor (A<sub>2A</sub>R) has emerged as a potential non-dopaminergic target for the treatment of Parkinson's disease and, thus, the non-invasive imaging with positron emission tomography (PET) is of utmost importance to monitor the receptor expression and occupancy during an A<sub>2A</sub>R-tailored therapy. Aiming at the development of a PET radiotracer, we herein report the design of a series of novel fluorinated analogs (<b>TOZ1</b>-<b>TOZ7</b>) based on the str ...[more]