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Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier.

ABSTRACT: Recent insights into the immunostimulatory properties of nucleic acid nanoparticles (NANPs) have demonstrated that variations in the shape, size, and composition lead to distinct patterns in their immunostimulatory properties. While most of these studies have used a single lipid-based carrier to allow for NANPs' intracellular delivery, it is now apparent that the platform for delivery, which has historically been a hurdle for therapeutic nucleic acids, is an additional means to tailoring NANP immunorecognition. Here, the use of dendrimers for the delivery of NANPs is compared to the lipid-based platform and the differences in resulting cytokine induction are presented.

SUBMITTER: Avila YI

PROVIDER: S-EPMC7865455 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier.

Avila Yelixza I YI Chandler Morgan M Cedrone Edward E Newton Hannah S HS Richardson Melina M Xu Jie J Clogston Jeffrey D JD Liptrott Neill J NJ Afonin Kirill A KA Dobrovolskaia Marina A MA

Molecules (Basel, Switzerland) 20210127 3

Recent insights into the immunostimulatory properties of nucleic acid nanoparticles (NANPs) have demonstrated that variations in the shape, size, and composition lead to distinct patterns in their immunostimulatory properties. While most of these studies have used a single lipid-based carrier to allow for NANPs' intracellular delivery, it is now apparent that the platform for delivery, which has historically been a hurdle for therapeutic nucleic acids, is an additional means to tailoring NANP im ...[more]

PMID: 33513786

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