Ontology highlight
ABSTRACT:
SUBMITTER: Calabretta MM
PROVIDER: S-EPMC7865915 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Calabretta Maria Maddalena MM Lopreside Antonia A Montali Laura L Cevenini Luca L Roda Aldo A Michelini Elisa E
Sensors (Basel, Switzerland) 20210129 3
In recent years, there has been an increasing demand for predictive and sensitive in vitro tools for drug discovery. Split complementation assays have the potential to enlarge the arsenal of in vitro tools for compound screening, with most of them relying on well-established reporter gene assays. In particular, ligand-induced complementation of split luciferases is emerging as a suitable approach for monitoring protein-protein interactions. We hereby report an intracellular nanosensor for the sc ...[more]