Ontology highlight
ABSTRACT:
SUBMITTER: Asch N
PROVIDER: S-EPMC7869429 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Asch Nir N Herschman Yehuda Y Maoz Rotem R Auerbach-Asch Carmel R CR Valsky Dan D Abu-Snineh Muneer M Arkadir David D Linetsky Eduard E Eitan Renana R Marmor Odeya O Bergman Hagai H Israel Zvi Z
Brain communications 20200529 2
Tremor is a core feature of Parkinson's disease and the most easily recognized Parkinsonian sign. Nonetheless, its pathophysiology remains poorly understood. Here, we show that multispectral spiking activity in the posterior-dorso-lateral oscillatory (motor) region of the subthalamic nucleus distinguishes resting tremor from the other Parkinsonian motor signs and strongly correlates with its severity. We evaluated microelectrode-spiking activity from the subthalamic dorsolateral oscillatory regi ...[more]