The effect of oral low molecular weight liquid hyaluronic acid combination with glucosamine and chondroitin on knee osteoarthritis patients with mild knee pain: An 8-week randomized double-blind placebo-controlled trial.

ABSTRACT:

Background

The popularity of dietary supplements for knee osteoarthritis (OA) management is on the rise; however, their effects are still debated.

Methods

This study aimed to investigate the effect of an oral low molecular weight liquid hyaluronic acid supplement in the treatment of knee OA patients with mild knee pain (visual analogue scale [VAS]???3) in Taiwan population. This was a randomized, double-blind, placebo-controlled study. Forty-seven subjects were enrolled and randomly allocated to either the A+HA or the placebo groups. The subjects were required to drink a bottle contained 20?mL of A+HA or placebo daily throughout an 8-week study period. The efficacy was assessed by using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the 36-item Short Form Survey (SF-36).

Results

At Week 8, significant reductions from baseline in the WOMAC pain (-2.6?±?1.68, P?ConclusionsOral administration of low molecular weight liquid HA appeared to be effective for knee OA patients with mild knee pain (VAS???3) in the relief of knee OA symptoms, particularly in pain and physical function.Clinical Trial Registration: NCT04352322.

SUBMITTER: Wang SJ 

PROVIDER: S-EPMC7870173 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature