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ABSTRACT: Background
The popularity of dietary supplements for knee osteoarthritis (OA) management is on the rise; however, their effects are still debated.Methods
This study aimed to investigate the effect of an oral low molecular weight liquid hyaluronic acid supplement in the treatment of knee OA patients with mild knee pain (visual analogue scale [VAS]???3) in Taiwan population. This was a randomized, double-blind, placebo-controlled study. Forty-seven subjects were enrolled and randomly allocated to either the A+HA or the placebo groups. The subjects were required to drink a bottle contained 20?mL of A+HA or placebo daily throughout an 8-week study period. The efficacy was assessed by using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the 36-item Short Form Survey (SF-36).Results
At Week 8, significant reductions from baseline in the WOMAC pain (-2.6?±?1.68, P?ConclusionsOral administration of low molecular weight liquid HA appeared to be effective for knee OA patients with mild knee pain (VAS???3) in the relief of knee OA symptoms, particularly in pain and physical function.Clinical Trial Registration: NCT04352322.
SUBMITTER: Wang SJ
PROVIDER: S-EPMC7870173 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Medicine 20210201 5
<h4>Background</h4>The popularity of dietary supplements for knee osteoarthritis (OA) management is on the rise; however, their effects are still debated.<h4>Methods</h4>This study aimed to investigate the effect of an oral low molecular weight liquid hyaluronic acid supplement in the treatment of knee OA patients with mild knee pain (visual analogue scale [VAS] ≤ 3) in Taiwan population. This was a randomized, double-blind, placebo-controlled study. Forty-seven subjects were enrolled and random ...[more]