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Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials.

ABSTRACT: Toxicogenomics (TGx) approaches are increasingly applied to gain insight into the possible toxicity mechanisms of engineered nanomaterials (ENMs). Omics data can be valuable to elucidate the mechanism of action of chemicals and to develop predictive models in toxicology. While vast amounts of transcriptomics data from ENM exposures have already been accumulated, a unified, easily accessible and reusable collection of transcriptomics data for ENMs is currently lacking. In an attempt to improve the FAIRness of already existing transcriptomics data for ENMs, we curated a collection of homogenized transcriptomics data from human, mouse and rat ENM exposures in vitro and in vivo including the physicochemical characteristics of the ENMs used in each study.

SUBMITTER: Saarimaki LA

PROVIDER: S-EPMC7870661 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials.

Saarimäki Laura Aliisa LA Federico Antonio A Lynch Iseult I Papadiamantis Anastasios G AG Tsoumanis Andreas A Melagraki Georgia G Afantitis Antreas A Serra Angela A Greco Dario D

Scientific data 20210208 1

Toxicogenomics (TGx) approaches are increasingly applied to gain insight into the possible toxicity mechanisms of engineered nanomaterials (ENMs). Omics data can be valuable to elucidate the mechanism of action of chemicals and to develop predictive models in toxicology. While vast amounts of transcriptomics data from ENM exposures have already been accumulated, a unified, easily accessible and reusable collection of transcriptomics data for ENMs is currently lacking. In an attempt to improve th ...[more]

PMID: 33558569

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