Ontology highlight
ABSTRACT:
SUBMITTER: Montnach J
PROVIDER: S-EPMC7870888 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Montnach Jérôme J Lorenzini Maxime M Lesage Adrien A Simon Isabelle I Nicolas Sébastien S Moreau Eléonore E Marionneau Céline C Baró Isabelle I De Waard Michel M Loussouarn Gildas G
Scientific reports 20210208 1
The patch-clamp technique and more recently the high throughput patch-clamp technique have contributed to major advances in the characterization of ion channels. However, the whole-cell voltage-clamp technique presents certain limits that need to be considered for robust data generation. One major caveat is that increasing current amplitude profoundly impacts the accuracy of the biophysical analyses of macroscopic ion currents under study. Using mathematical kinetic models of a cardiac voltage-g ...[more]