Phenethyisoquinoline alkaloids from the leaves of Androcymbium palaestinum.

ABSTRACT: Thirteen compounds were isolated from the methanolic extract of the leaves of Androcymbium palaestinum Baker (Colchicaceae). Of these, three were new, two were new natural products, and eight were known. The new isolated compounds were (+)-1-demethylandrocine (5), (-)-andropalaestine (8), and (+)-2-demethyl-β-lumicolchicone (10), while the new natural products were (+)-O-methylkreysigine-N-oxide (3) and (+)-O,O-dimethylautumnaline (9). Moreover, two known compounds are reported for the first time from this species, specifically (-)-colchicine (11) and (-)-3-demethyldemecolcine (13). The structures of the isolated compounds were elucidated using a series of spectroscopic and spectrometric techniques, principally HRESIMS, 1D-NMR (¹H and ¹³C NMR) and 2D-NMR (COSY, edited

SUBMITTER: El-Elimat T 

PROVIDER: S-EPMC7871506 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature