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Ethnic-specific association of amylase gene copy number with adiposity traits in a large Middle Eastern biobank.


ABSTRACT: Studies assessing the impact of amylase genes copy number (CN) on adiposity report conflicting findings in different global populations, likely reflecting the impact of ancestral and ethnic-specific environment and lifestyle on selection at the amylase loci. Here, we leverage population size and detailed adiposity measures from a large population biobank to resolve confounding effects and determine the relationship between salivary (AMY1) and pancreatic (AMY2A) amylase genes CN and adiposity in 2935 Qatari individuals who underwent whole-genome sequencing (WGS) as part of the Qatar Genome Programme. We observe a negative association between AMY1 CNs and trunk fat percentage in the Qatari population (P?=?7.50?×?10-3) and show that Qataris of Arab descent have significantly lower CN at AMY1 (P?=?1.32?×?10-10) as well as less favorable adiposity and metabolic profiles (P?-8) than Qataris with Persian ancestry. Indeed, lower AMY1 CN was associated with increased total and trunk fat percentages in Arabs (P?-3) but not in Persians. Notably, overweight and obese Persians reported a significant trend towards dietary restraint following weight gain compared to Arabs (P?=?4.29?×?10-5), with AMY1 CN showing negative association with dietary self-restraint (P?=?3.22?×?10-3). This study reports an association between amylase gene CN and adiposity traits in a large Middle Eastern population. Importantly, we leverage rich biobank data to demonstrate that the strength of this association varies with ethnicity, and may be influenced by population-specific behaviors that also contribute to adiposity traits.

SUBMITTER: Rossi N 

PROVIDER: S-EPMC7873199 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Ethnic-specific association of amylase gene copy number with adiposity traits in a large Middle Eastern biobank.

Rossi Niccolo' N   Aliyev Elbay E   Visconti Alessia A   Akil Ammira S A ASA   Syed Najeeb N   Aamer Waleed W   Padmajeya Sujitha S SS   Falchi Mario M   Fakhro Khalid A KA  

NPJ genomic medicine 20210209 1


Studies assessing the impact of amylase genes copy number (CN) on adiposity report conflicting findings in different global populations, likely reflecting the impact of ancestral and ethnic-specific environment and lifestyle on selection at the amylase loci. Here, we leverage population size and detailed adiposity measures from a large population biobank to resolve confounding effects and determine the relationship between salivary (AMY1) and pancreatic (AMY2A) amylase genes CN and adiposity in  ...[more]

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