Ontology highlight
ABSTRACT:
SUBMITTER: Tyrrell J
PROVIDER: S-EPMC7873270 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Nature communications 20210209 1
Large studies such as UK Biobank are increasingly used for GWAS and Mendelian randomization (MR) studies. However, selection into and dropout from studies may bias genetic and phenotypic associations. We examine genetic factors affecting participation in four optional components in up to 451,306 UK Biobank participants. We used GWAS to identify genetic variants associated with participation, MR to estimate effects of phenotypes on participation, and genetic correlations to compare participation ...[more]