Ontology highlight
ABSTRACT:
SUBMITTER: Yang F
PROVIDER: S-EPMC7873714 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Yang Feifei F Medik Yusra Y Li Liantao L Tian Xi X Fu Dong D Brouwer Kim L R KLR Wagner Kyle K Sun Bo B Sendi Hossein H Mi Yu Y Wang Andrew Z AZ
Small (Weinheim an der Bergstrasse, Germany) 20200123 7
Hepatotoxicity is a key concern in the clinical translation of nanotherapeutics because preclinical studies have consistently shown that nanotherapeutics accumulates extensively in the liver. However, clinical-stage nanotherapeutics have not shown increased hepatotoxicity. Factors that can contribute to the hepatotoxicity of nanotherapeutics beyond the intrinsic hepatotoxicity of nanoparticles (NPs) are poorly understood. Because of this knowledge gap, clinical translation efforts have avoided h ...[more]