Unknown

Dataset Information

0

Regeneration Profiles of Olfactory Epithelium after SARS-CoV-2 Infection in Golden Syrian Hamsters.

ABSTRACT: Olfactory dysfunction is one of the most frequent and specific symptoms of coronavirus disease 2019 (COVID-19). Information on the damage and repair of the neuroepithelium and its impact on olfactory function after COVID-19 is still incomplete. While severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes the ongoing worldwide outbreak of COVID-19, little is known about the changes triggered by SARS-CoV-2 in the olfactory epithelium (OE) at the cellular level. Here, we report profiles of the OE after SARS-CoV-2 infection in golden Syrian hamsters, which is a reliable animal model of COVID-19. We observed severe damage in the OE as early as 3 days postinoculation and regionally specific damage and regeneration of the OE within the nasal cavity; the nasal septal region demonstrated the fastest recovery compared to other regions in the nasal turbinates. These findings suggest that anosmia related to SARS-CoV-2 infection may be fully reversible.

SUBMITTER: Urata S 

PROVIDER: S-EPMC7874468 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Regeneration Profiles of Olfactory Epithelium after SARS-CoV-2 Infection in Golden Syrian Hamsters.

Urata Shinji S   Maruyama Junki J   Kishimoto-Urata Megumi M   Sattler Rachel A RA   Cook Rebecca R   Lin Nantian N   Yamasoba Tatsuya T   Makishima Tomoko T   Paessler Slobodan S  

ACS chemical neuroscience 20210201 4

Olfactory dysfunction is one of the most frequent and specific symptoms of coronavirus disease 2019 (COVID-19). Information on the damage and repair of the neuroepithelium and its impact on olfactory function after COVID-19 is still incomplete. While severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes the ongoing worldwide outbreak of COVID-19, little is known about the changes triggered by SARS-CoV-2 in the olfactory epithelium (OE) at the cellular level. Here, we report profile  ...[more]

Similar Datasets

Unknown Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters.
| S-EPMC7332942 | biostudies-literature
Unknown Progression and Resolution of SARS-CoV-2 Infection in Golden Syrian Hamsters.
| S-EPMC8577872 | biostudies-literature
Unknown SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters.
| S-EPMC9085785 | biostudies-literature
Unknown SARS-CoV-2 infection induces persistent adipose tissue damage in aged golden Syrian hamsters.
| S-EPMC9891765 | biostudies-literature
Unknown Oral SARS-CoV-2 Inoculation Establishes Subclinical Respiratory Infection with Virus Shedding in Golden Syrian Hamsters.
| S-EPMC7508015 | biostudies-literature
Unknown Hepatic endotheliitis in Golden Syrian hamsters (Mesocricetus auratus) experimentally infected with SARS-CoV-2.
| S-EPMC11295288 | biostudies-literature
Transcriptomics Prior influenza infection mitigates SARS-CoV-2 disease in Syrian hamsters
2024-02-05 | GSE254516 | GEO
Unknown Immunization with V987H-stabilized Spike glycoprotein protects K18-hACE2 mice and golden Syrian hamsters upon SARS-CoV-2 infection.
| S-EPMC10957958 | biostudies-literature
Unknown Vasculitis and Neutrophil Extracellular Traps in Lungs of Golden Syrian Hamsters With SARS-CoV-2.
| S-EPMC8072219 | biostudies-literature
Transcriptomics Brd2 inhibitor ABBV-744 inhibits SARS-CoV-2 infection in Syrian Hamsters
2021-09-02 | GSE182994 | GEO