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The right immune-modulation at the right time: thymosin ?1 for prevention of severe COVID-19 in cancer patients.


ABSTRACT: We presented the rationale for the use of thymosin ?1 as prophylaxis of severe COVID-19 in cancer patients undergoing active treatment, constituting the background for the PROTHYMOS study, a prospective, multicenter, open-label, Phase II randomized study, currently in its start-up phase (Eudract no. 2020-006020-13). We aim to offer new hope for this incurable disease, especially to frail patient population, such as patients with cancer. The hypothesis of an effective prophylactic approach to COVID-19 would have immediate clinical relevance, especially given the lack of curative approaches. Moreover, in the 'COVID-19 vaccine race era' both clinical and biological results coming from the PROTHYMOS trials could even support the rationale for future combinatorial approaches, trying to rise vaccine efficacy in frail individuals.

SUBMITTER: Bersanelli M 

PROVIDER: S-EPMC7874885 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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The right immune-modulation at the right time: thymosin α1 for prevention of severe COVID-19 in cancer patients.

Bersanelli Melissa M   Giannarelli Diana D   Leonetti Alessandro A   Buti Sebastiano S   Tiseo Marcello M   Nouvenne Antonio A   Ticinesi Andrea A   Meschi Tiziana T   Procopio Giuseppe G   Danielli Riccardo R  

Future oncology (London, England) 20210204 9


We presented the rationale for the use of thymosin α1 as prophylaxis of severe COVID-19 in cancer patients undergoing active treatment, constituting the background for the PROTHYMOS study, a prospective, multicenter, open-label, Phase II randomized study, currently in its start-up phase (Eudract no. 2020-006020-13). We aim to offer new hope for this incurable disease, especially to frail patient population, such as patients with cancer. The hypothesis of an effective prophylactic approach to COV  ...[more]

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