Unknown

Dataset Information

0

Association between cotinine-verified smoking status and moderately increased albuminuria in the middle-aged and older population in Korea: A nationwide population-based study.


ABSTRACT:

Objectives

Although several self-reported questionnaire-based studies have found an association between smoking and moderately increased albuminuria, this result remains controversial. We investigated whether moderately increased albuminuria was associated with smoking status, verified by urinary cotinine (an objective biomarker of tobacco exposure), using population-based, nationally representative data.

Methods

This study included 2059 participants aged ? 50 years from the 2014 Korean National Health and Nutrition Examination Survey. Individuals with a urinary cotinine level ? 50 ng/mL were identified as cotinine-verified smokers. Moderately increased albuminuria was defined as a urine albumin-to-creatinine ratio ranging between ? 30 mg/g and < 300 mg/g. Multivariable logistic regression was used to evaluate the association between cotinine-verified smoking status and moderately increased albuminuria.

Results

Among the study participants, 16.9% were cotinine-verified smokers, 84.8% of whom were men. After adjustment for multiple covariates, cotinine-verified smokers showed a significant positive association with moderately increased albuminuria (adjusted odds ratio: 4.37, 95% confidence interval: 1.63-11.71) compared with cotinine-verified non-smokers. The association between urinary cotinine and moderately increased albuminuria did not differ with age, sex, obesity, or comorbidities (P-value for interaction > 0.05 in all cases).

Conclusion

This large-scale observational study showed that cotinine-verified smoking is associated with moderately increased albuminuria in the Korean middle-aged and older general population, suggesting that smoking must be strictly controlled to reduce the risk of moderately increased albuminuria.

SUBMITTER: Choi Y 

PROVIDER: S-EPMC7875375 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

altmetric image

Publications

Association between cotinine-verified smoking status and moderately increased albuminuria in the middle-aged and older population in Korea: A nationwide population-based study.

Choi Yeonjoo Y   Park Joo-Hyun JH   Kim Do-Hoon DH   Kim Hyun Jin HJ   Suh Euijung E   Kim Ki-Hoon KH   Ahn Jae Joon JJ   Lee Gyu-Na GN   Jung Jin-Hyung JH   Han Kyungdo K   Shin You-Na YN  

PloS one 20210210 2


<h4>Objectives</h4>Although several self-reported questionnaire-based studies have found an association between smoking and moderately increased albuminuria, this result remains controversial. We investigated whether moderately increased albuminuria was associated with smoking status, verified by urinary cotinine (an objective biomarker of tobacco exposure), using population-based, nationally representative data.<h4>Methods</h4>This study included 2059 participants aged ≥ 50 years from the 2014  ...[more]

Similar Datasets

| S-EPMC7557215 | biostudies-literature
| S-EPMC7458848 | biostudies-literature
| S-EPMC8047000 | biostudies-literature
| S-EPMC8049314 | biostudies-literature
| S-EPMC7148336 | biostudies-literature
| S-EPMC5541452 | biostudies-literature
| S-EPMC5666535 | biostudies-literature
| S-EPMC5256309 | biostudies-literature
| S-EPMC8369207 | biostudies-literature
| S-EPMC5980562 | biostudies-literature