Ontology highlight
ABSTRACT:
SUBMITTER: Liu JL
PROVIDER: S-EPMC7876468 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Liu Jinny L JL Webb Emily M EM Zabetakis Dan D Burke Crystal W CW Gardner Christina L CL Glass Pamela J PJ Legler Patricia M PM Weger-Lucarelli James J Anderson George P GP Goldman Ellen R ER
Frontiers in medicine 20210128
A single domain antibody (clone CC3) previously found to neutralize a vaccine strain of the chikungunya virus (PRNT<sub>50</sub> = 2. 5 ng/mL) was found to be broadly neutralizing. Clone CC3 is not only able to neutralize a wild-type (WT) strain of chikungunya virus (CHIKV), but also neutralizes WT strains of Mayaro virus (MAYV) and Ross River virus (RRV); both arthralgic, Old World alphaviruses. Interestingly, CC3 also demonstrated a degree of neutralizing activity against the New World alphavi ...[more]