Ontology highlight
ABSTRACT:
SUBMITTER: Philip H
PROVIDER: S-EPMC7876555 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Philip Hagit H Snir Tom T Gordin Miri M Shugay Mikhail M Zilberberg Alona A Efroni Sol S
iScience 20210127 2
Biology of the response to anti-CTLA-4 involves the dynamics of specific T cell clones. Reasons for clinical success and failure of this treatment are still largely unknown. Here, we quantified the dynamics of the T cell receptor (TCR) repertoire, throughout 4 weeks involving treatment with anti-CTLA-4, in a syngeneic mouse model for colorectal cancer. These dynamics show an initial increase in clonality in tandem with a decrease in diversity, effects which gradually subside. Furthermore, respon ...[more]