Unknown

Dataset Information

0

A T cell repertoire timestamp is at the core of responsiveness to CTLA-4 blockade.


ABSTRACT: Biology of the response to anti-CTLA-4 involves the dynamics of specific T cell clones. Reasons for clinical success and failure of this treatment are still largely unknown. Here, we quantified the dynamics of the T cell receptor (TCR) repertoire, throughout 4 weeks involving treatment with anti-CTLA-4, in a syngeneic mouse model for colorectal cancer. These dynamics show an initial increase in clonality in tandem with a decrease in diversity, effects which gradually subside. Furthermore, response to treatment is tightly connected to the shared and public parts of the T cell repertoire. We were able to recognize time-dependent behaviors of specific TCR sequences and cell types and to show the response is dominated by specific motifs. We see that a single, specific time point might be useful to inform a physician of the true response to treatmentThe research further highlights the importance of temporal analyses of the immune response.

SUBMITTER: Philip H 

PROVIDER: S-EPMC7876555 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

A T cell repertoire timestamp is at the core of responsiveness to CTLA-4 blockade.

Philip Hagit H   Snir Tom T   Gordin Miri M   Shugay Mikhail M   Zilberberg Alona A   Efroni Sol S  

iScience 20210127 2


Biology of the response to anti-CTLA-4 involves the dynamics of specific T cell clones. Reasons for clinical success and failure of this treatment are still largely unknown. Here, we quantified the dynamics of the T cell receptor (TCR) repertoire, throughout 4 weeks involving treatment with anti-CTLA-4, in a syngeneic mouse model for colorectal cancer. These dynamics show an initial increase in clonality in tandem with a decrease in diversity, effects which gradually subside. Furthermore, respon  ...[more]

Similar Datasets

| S-EPMC6020019 | biostudies-literature
| S-EPMC5398199 | biostudies-literature
| S-EPMC6279422 | biostudies-literature
| S-EPMC3666941 | biostudies-literature
| S-EPMC4008652 | biostudies-literature
| S-EPMC6791420 | biostudies-literature
| S-EPMC7079427 | biostudies-literature
| S-EPMC7349993 | biostudies-literature
| S-EPMC4430259 | biostudies-other
| S-EPMC6286242 | biostudies-literature