Ontology highlight
ABSTRACT:
SUBMITTER: Genoud V
PROVIDER: S-EPMC6279422 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Oncoimmunology 20180905 12
Immune checkpoint blockade (ICB) is currently evaluated in patients with glioblastoma (GBM), based on encouraging clinical data in other cancers, and results from studies with the methylcholanthrene-induced GL261 mouse glioma. In this paper, we describe a novel model faithfully recapitulating some key human GBM characteristics, including low mutational load, a factor reported as a prognostic indicator of ICB response. Consistent with this observation, SB28 is completely resistant to ICB, contras ...[more]