Ontology highlight
ABSTRACT:
SUBMITTER: Genoud V
PROVIDER: S-EPMC6279422 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Genoud Vassilis V Marinari Eliana E Nikolaev Sergey I SI Castle John C JC Bukur Valesca V Dietrich Pierre-Yves PY Okada Hideho H Walker Paul R PR
Oncoimmunology 20180905 12
Immune checkpoint blockade (ICB) is currently evaluated in patients with glioblastoma (GBM), based on encouraging clinical data in other cancers, and results from studies with the methylcholanthrene-induced GL261 mouse glioma. In this paper, we describe a novel model faithfully recapitulating some key human GBM characteristics, including low mutational load, a factor reported as a prognostic indicator of ICB response. Consistent with this observation, SB28 is completely resistant to ICB, contras ...[more]