Dataset Information

Validation and application of OCT tissue attenuation index for the detection of neointimal foam cells.

ABSTRACT: Neointimal infiltration with foamy macrophages is recognized as an early and important sign of de-novo atherosclerosis after stent implantation (neoatherosclerosis). Recent histopathological studies have proven that automated quantification of signal attenuation using intravascular optical coherence tomography (OCT) imaging allows for sensitive identification of macrophages in native atherosclerotic disease. Whether this is true for neointimal foam cells in the setting of neoatherosclerosis remains unknown. Autopsy samples of stented coronary arteries (n?=?13 cases) were evaluated by histology and OCT. After co-registration with histology, the attenuation rate of emitted laser light was measured in regions with and without neointimal foamy macrophages relative to its peak intensity at the blood-tissue interface. Attenuation index was subsequently determined as slope of a regression curve fitted to individual data points. Receiver operating curve (ROC) analysis was used to establish an optimal cut-off for detecting foamy macrophages in homogenous and non-homogenous neointima, respectively. Finally, the tissue attenuation index was applied to confirm or exclude the presence of neointimal foamy macrophages in symptomatic patients presenting with in-stent restenosis and undergoing intravascular OCT imaging (n?=?29 cases). Tissue attenuation index derived from post-mortem samples differed significantly between histologically confirmed regions with and without neointimal foamy macrophages (- 1.23?±?1.42 vs. - 0.52?±?1.79, p?

SUBMITTER: Nicol P

PROVIDER: S-EPMC7878214 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Validation and application of OCT tissue attenuation index for the detection of neointimal foam cells.

Nicol Philipp P Hoppman Petra P Euller Kristina K Xhepa Erion E Lenz Tobias T Rai Himanshu H Jinnouchi Hiroyuki H Bulin Anna A Castellanos Maria Isabel MI Lahmann Anna Lena AL Koppara Tobias T Kastrati Adnan A Joner Michael M

The international journal of cardiovascular imaging 20200806 1

Neointimal infiltration with foamy macrophages is recognized as an early and important sign of de-novo atherosclerosis after stent implantation (neoatherosclerosis). Recent histopathological studies have proven that automated quantification of signal attenuation using intravascular optical coherence tomography (OCT) imaging allows for sensitive identification of macrophages in native atherosclerotic disease. Whether this is true for neointimal foam cells in the setting of neoatherosclerosis rema ...[more]

PMID: 32761285

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Project description:OBJECTIVE:The Tinnitus Functional Index (TFI) is a new diagnostic measure of the functional impact of tinnitus that is also a sensitive measure of treatment-related changes. However, the TFI has not been translated into Chinese and fully validated in China. The aim of the present study was to evaluate the validity of a Chinese version of the TFI as a diagnostic measure of tinnitus severity in a sample of Chinese patients and to verify the value of its clinical application in China. DESIGN:A sample of 206 patients whose primary complaint was tinnitus was used to analyze the reliability and validity of the TFI. In addition, patients were asked to fill out the Tinnitus Handicap Inventory (THI) and the Center for Epidemiologic Studies-Depression Scale (CES-D), the Beck Anxiety Inventory (BAI), and the Satisfaction With Life Scale (SWLS) to compare TFI with their association. The internal consistency of the TFI was assessed with Cronbach's alpha coefficient. The factor structure of the TFI was assessed by Exploratory Factor Analysis (EFA). The extracted factors were compared to those of the original TFI scale. RESULTS:The reliability of the Chinese version of the TFI (Cronbach' s ??=?.969) showed high internal consistency. The exploratory factor analysis (EFA) of the TFI showed that six factors with one main factor could be extracted instead of eight factors as described in the original version. Nevertheless, relations to the original eight subscales could be demonstrated. A high correlation between the TFI and the THI (r?=?.865, p?<?0.01) and lower correlations between the TFI and the CES-D (r?=?.334, p?<?0.01), BAI (r?=?.559, p?<?0.01), and SWLS (r?=?-?0.324, p?<?0.01) confirmed the satisfactory convergent and discriminant validity of the TFI. CONCLUSION:After translated and validated a Chinese version of the TFI and found that the TFI had high reliability and validity, which means both instruments are reliable instruments to assess the severity of tinnitus in clinical applications in China.

Dataset Information

Validation and application of OCT tissue attenuation index for the detection of neointimal foam cells.

Publications

Validation and application of OCT tissue attenuation index for the detection of neointimal foam cells.

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