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Correlation between toxicity and dosimetric parameters for adjuvant intensity modulated radiation therapy of breast cancer: a prospective study.


ABSTRACT:

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0000-0001-6019-7309. In the treatment of breast cancer, intensity-modulated radiation therapy (IMRT) reportedly reduces the high-dose irradiation of at-risk organs and decreases the frequency of adverse events (AEs). Comparisons with conventional radiotherapy have shown that IMRT is associated with lower frequencies of acute and late-onset AEs. Here, we extended a prospective, observational, single-center study of the safety of IMRT to a second investigating center. Patients scheduled for adjuvant IMRT after partial or total mastectomy were given a dose of 50 Gy (25 fractions of 2 Gy over 5 weeks), with a simultaneous integrated boost in patients having undergone conservative surgery. 300 patients were included in the study, and 288 were analyzed. The median follow-up period was 2.1 years. The 2-year disease-free survival rate [95% CI] was 93.4% [89.2-96.0%]. Most AEs were mild. The most common AEs were skin-related-mainly radiodermatitis [in 266 patients (92.4%)] and hyperpigmentation (in 178 (61.8%)). 35% and 6% of the patients presented with grade 2 acute skin and esophageal toxicity, respectively. Only 4 patients presented with a grade 3 event (radiodermatitis). Smoking (odds ratio) [95% CI]?=?2.10 [1.14-3.87]; p?=?0.017), no prior chemotherapy (0.52 [0.27-0.98]; p?=?0.044), and D98% for subclavicular skin (1.030 [1.001-1.061]; p?=?0.045) were associated with grade???2 acute AEs. In a univariate analysis, the mean dose, (p?Trial registrationClinicalTrials.gov NCT02281149.

SUBMITTER: Pasquier D 

PROVIDER: S-EPMC7878810 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

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Correlation between toxicity and dosimetric parameters for adjuvant intensity modulated radiation therapy of breast cancer: a prospective study.

Pasquier David D   Bataille Benoit B   Le Tinier Florence F   Bennadji Raoudha R   Langin Hélène H   Escande Alexandre A   Tresch Emmanuelle E   Darloy Franck F   Carlier Damien D   Crop Frederik F   Lartigau Eric E  

Scientific reports 20210211 1


<h4>Orcid</h4>0000-0001-6019-7309. In the treatment of breast cancer, intensity-modulated radiation therapy (IMRT) reportedly reduces the high-dose irradiation of at-risk organs and decreases the frequency of adverse events (AEs). Comparisons with conventional radiotherapy have shown that IMRT is associated with lower frequencies of acute and late-onset AEs. Here, we extended a prospective, observational, single-center study of the safety of IMRT to a second investigating center. Patients schedu  ...[more]

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