Ontology highlight
ABSTRACT:
SUBMITTER: Cohen JT
PROVIDER: S-EPMC7878835 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Cohen Joshua T JT Danise Michael M Machan Jason T JT Zhao Runping R Lefort Craig T CT
Stem cell reports 20210121 2
Hemorrhagic shock induces an aberrant immune response characterized by simultaneous induction of a proinflammatory state and impaired host defenses. The objective of this study was to evaluate the impact of conditionally immortalized neutrophil progenitors (NPs) on this aberrant immune response. We employed a mouse model of hemorrhagic shock, followed by the adoptive transfer of NPs and subsequent inoculation of Staphylococcus aureus to induce pneumonia. We observed that transplant of NPs decrea ...[more]