Dataset Information

NASH-related increases in plasma bile acid levels depend on insulin resistance.

ABSTRACT:

Background & aims

Plasma bile acids (BAs) have been extensively studied as pathophysiological actors in non-alcoholic steatohepatitis (NASH). However, results from clinical studies are often complicated by the association of NASH with type 2 diabetes (T2D), obesity, and insulin resistance (IR). Here, we sought to dissect the relationship between NASH, T2D, and plasma BA levels in a large patient cohort.

Methods

Four groups of patients from the Biological Atlas of Severe Obesity (ABOS) cohort (Clinical Trials number NCT01129297) were included based on the presence or absence of histologically evaluated NASH with or without coincident T2D. Patients were matched for BMI, homeostatic model assessment 2 (HOMA2)-assessed IR, glycated haemoglobin, age, and gender. To study the effect of IR and BMI on the association of plasma BA and NASH, patients from the HEPADIP study were included. In both cohorts, fasting plasma BA concentrations were measured.

Results

Plasma BA concentrations were higher in NASH compared with No-NASH patients both in T2D and NoT2D patients from the ABOS cohort. As we previously reported that plasma BA levels were unaltered in NASH patients of the HEPADIP cohort, we assessed the impact of BMI and IR on the association of NASH and BA on the combined BA datasets. Our results revealed that NASH-associated increases in plasma total cholic acid (CA) concentrations depend on the degree of HOMA2-assessed systemic IR, but not on ?-cell function nor on BMI.

Conclusions

Plasma BA concentrations are elevated only in those NASH patients exhibiting pronounced IR.

Lay summary

Non-alcoholic steatohepatitis (NASH) is a progressive liver disease that frequently occurs in patients with obesity and type 2 diabetes. Reliable markers for the diagnosis of NASH are needed. Plasma bile acids have been proposed as NASH biomarkers. Herein, we found that plasma bile acids are only elevated in patients with NASH when significant insulin resistance is present, limiting their utility as NASH markers.

SUBMITTER: Grzych G

PROVIDER: S-EPMC7878982 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature

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Publications

NASH-related increases in plasma bile acid levels depend on insulin resistance.

Grzych Guillaume G Chávez-Talavera Oscar O Descat Amandine A Thuillier Dorothée D Verrijken An A Kouach Mostafa M Legry Vanessa V Verkindt Hélène H Raverdy Violeta V Legendre Benjamin B Caiazzo Robert R Van Gaal Luc L Goossens Jean-Francois JF Paumelle Réjane R Francque Sven S Pattou François F Haas Joel T JT Tailleux Anne A Staels Bart B

JHEP reports : innovation in hepatology 20201216 2

<h4>Background & aims</h4>Plasma bile acids (BAs) have been extensively studied as pathophysiological actors in non-alcoholic steatohepatitis (NASH). However, results from clinical studies are often complicated by the association of NASH with type 2 diabetes (T2D), obesity, and insulin resistance (IR). Here, we sought to dissect the relationship between NASH, T2D, and plasma BA levels in a large patient cohort.<h4>Methods</h4>Four groups of patients from the Biological Atlas of Severe Obesity (A ...[more]

PMID: 33615207

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Dataset Information

NASH-related increases in plasma bile acid levels depend on insulin resistance.

Background & aims

Methods

Results

Conclusions

Lay summary

Publications

NASH-related increases in plasma bile acid levels depend on insulin resistance.

Similar Datasets

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