Ontology highlight
ABSTRACT:
SUBMITTER: Haeusler RA
PROVIDER: S-EPMC3837033 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Haeusler Rebecca A RA Astiarraga Brenno B Camastra Stefania S Accili Domenico D Ferrannini Ele E
Diabetes 20130724 12
Bile acids (BAs) exert pleiotropic metabolic effects, and physicochemical properties of different BAs affect their function. In rodents, insulin regulates BA composition, in part by regulating the BA 12α-hydroxylase CYP8B1. However, it is unclear whether a similar effect occurs in humans. To address this question, we examined the relationship between clamp-measured insulin sensitivity and plasma BA composition in a cohort of 200 healthy subjects and 35 type 2 diabetic (T2D) patients. In healthy ...[more]