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A population scale analysis of rare SNCA variation in the UK Biobank.

ABSTRACT: Parkinson's disease (PD) is a complex neurodegenerative disease with a variety of genetic and environmental factors contributing to disease. The SNCA gene encodes for the alpha-synuclein protein which plays a central role in PD, where aggregates of this protein are one of the pathological hallmarks of disease. Rare point mutations and copy number gains of the SNCA gene have been shown to cause autosomal dominant PD, and common DNA variants identified using Genome-Wide Association Studies (GWAS) are a moderate risk factor for PD. The UK Biobank is a large-scale population prospective study including ~500,000 individuals that has revolutionized human genetics. Here we assessed the frequency of SNCA variation in this cohort and identified 30 subjects carrying variants of interest including duplications (n?=?6), deletions (n?=?6) and large complex likely mosaic events (n?=?18). No known pathogenic missense variants were identified. None of these subjects were reported to be a PD case, although it is possible that these individuals may develop PD at a later age, and whilst three had known prodromal features, these did not meet defined clinical criteria for being considered 'prodromal' cases. Seven of the 18 large complex carriers showed a history of blood based cancer. Overall, we identified copy number variants in the SNCA region in a large population based cohort without reported PD phenotype and symptoms. Putative mosaicism of the SNCA gene was identified, however, it is unclear whether it is associated with PD. These individuals are potential candidates for further investigation by performing SNCA RNA and protein expression studies, as well as promising clinical trial candidates to understand how duplication carriers potentially escape PD.

SUBMITTER: Blauwendraat C

PROVIDER: S-EPMC7880248 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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A population scale analysis of rare SNCA variation in the UK Biobank.

Blauwendraat Cornelis C Makarious Mary B MB Leonard Hampton L HL Bandres-Ciga Sara S Iwaki Hirotaka H Nalls Mike A MA Noyce Alastair J AJ Singleton Andrew B AB

Neurobiology of disease 20201208

Parkinson's disease (PD) is a complex neurodegenerative disease with a variety of genetic and environmental factors contributing to disease. The SNCA gene encodes for the alpha-synuclein protein which plays a central role in PD, where aggregates of this protein are one of the pathological hallmarks of disease. Rare point mutations and copy number gains of the SNCA gene have been shown to cause autosomal dominant PD, and common DNA variants identified using Genome-Wide Association Studies (GWAS) ...[more]

PMID: 33307186

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Dataset Information

A population scale analysis of rare SNCA variation in the UK Biobank.

Publications

A population scale analysis of rare SNCA variation in the UK Biobank.

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