Ontology highlight
ABSTRACT:
SUBMITTER: Feng GJ
PROVIDER: S-EPMC7880826 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Feng Gui-Juan GJ Wei Xin-Tong XT Zhang Hong H Yang Xiao-Lin XL Shen Hui H Tian Qing Q Deng Hong-Wen HW Zhang Lei L Pei Yu-Fang YF
Journal of human genetics 20200914 3
Bone mineral density (BMD) and lean body mass (LBM) not only have a considerable heritability each, but also are genetically correlated. However, common genetic determinants shared by both traits are largely unknown. In the present study, we performed a bivariate genome-wide association study (GWAS) meta-analysis of hip BMD and trunk lean mass (TLM) in 11,335 subjects from 6 samples, and performed replication in estimated heel BMD and TLM in 215,234 UK Biobank (UKB) participants. We identified 2 ...[more]