Dataset Information

Four pleiotropic loci associated with fat mass and lean mass.

ABSTRACT:

Background

Fat mass and lean mass are two biggest components of body mass. Both fat mass and lean mass are under strong genetic determinants and are correlated.

Methods

We performed a bivariate genome-wide association meta-analysis of (lean adjusted) leg fat mass and (fat adjusted) leg lean mass in 12,517 subjects from 6 samples, and followed by in silico replication in large-scale UK biobank cohort sample (N?=?370 097).

Results

We identified four loci that were significant at the genome-wide significance (GWS, ??=?5.0?×?10^-8) level at the discovery meta-analysis, and successfully replicated in the replication sample: 2q36.3 (rs1024137, p_discovery?=?3.32?×?10^-8, p_replication?=?4.07?×?10^-13), 5q13.1 (rs4976033, p_discovery?=?1.93?×?10^-9, p_replication?=?6.35?×?10^-7), 12q24.31 (rs4765528, p_discovery?=?7.19?×?10^-12, p_replication?=?1.88?×?10^-11) and 18q21.32 (rs371326986, p_discovery?=?9.04?×?10^-9, p_replication?=?2.35?×?10^-95). The above four pleiotropic loci may play a pleiotropic role for fat mass and lean mass development.

Conclusions

Our findings further enhance the understanding of the genetic association between fat mass and lean mass and provide a new theoretical basis for their understanding.

SUBMITTER: Liu Y

PROVIDER: S-EPMC7912634 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Publications

Four pleiotropic loci associated with fat mass and lean mass.

Liu Yu Y Ran Shu S Lin Yong Y Zhang Yu-Xue YX Yang Xiao-Lin XL Wei Xin-Tong XT Jiang Zi-Xuan ZX He Xiao X Zhang Hong H Feng Gui-Juan GJ Shen Hui H Tian Qing Q Deng Hong-Wen HW Zhang Lei L Pei Yu-Fang YF

International journal of obesity (2005) 20200727 10

<h4>Background</h4>Fat mass and lean mass are two biggest components of body mass. Both fat mass and lean mass are under strong genetic determinants and are correlated.<h4>Methods</h4>We performed a bivariate genome-wide association meta-analysis of (lean adjusted) leg fat mass and (fat adjusted) leg lean mass in 12,517 subjects from 6 samples, and followed by in silico replication in large-scale UK biobank cohort sample (N = 370 097).<h4>Results</h4>We identified four loci that were significant ...[more]

PMID: 32719433

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Dataset Information

Four pleiotropic loci associated with fat mass and lean mass.

Background

Methods

Results

Conclusions

Publications

Four pleiotropic loci associated with fat mass and lean mass.

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