Ontology highlight
ABSTRACT:
SUBMITTER: Song Y
PROVIDER: S-EPMC7881221 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Song Yunjin Y Jeong Hoibin H Kim Song-Rae SR Ryu Yiseul Y Baek Jonghwi J Kwon Jinhak J Cho Hyeongjun H Kim Kil-Nam KN Lee Joong-Jae JJ
iScience 20210129 2
Systematic control of <i>in vivo</i> behavior of protein-based therapeutics is considered highly desirable for improving their clinical outcomes. Modulation of biochemical properties including molecular weight, surface charge, and binding affinity has thus been suggested to enhance their therapeutic effects. However, establishing a relationship between the binding affinity and tumor localization remains a debated issue. Here we investigate the influence of the binding affinity of proteins on tum ...[more]