Ontology highlight
ABSTRACT:
SUBMITTER: Van Leuven JT
PROVIDER: S-EPMC7881332 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Van Leuven James T JT Ederer Martina M MM Burleigh Katelyn K Scott LuAnn L Hughes Randall A RA Codrea Vlad V Ellington Andrew D AD Wichman Holly A HA Miller Craig R CR
Genome biology and evolution 20210201 2
Natural selection acting on synonymous mutations in protein-coding genes influences genome composition and evolution. In viruses, introducing synonymous mutations in genes encoding structural proteins can drastically reduce viral growth, providing a means to generate potent, live-attenuated vaccine candidates. However, an improved understanding of what compositional features are under selection and how combinations of synonymous mutations affect viral growth is needed to predictably attenuate vi ...[more]