Dataset Information

CoDe: a web-based tool for codon deoptimization.

ABSTRACT:

Summary

We have developed a web-based tool, CoDe (Codon Deoptimization) that deoptimizes genetic sequences based on different codon usage bias, ultimately reducing expression of the corresponding protein. The tool could also deoptimize the sequence for a specific region and/or selected amino acid(s). Moreover, CoDe can highlight sites targeted by restriction enzymes in the wild-type and codon-deoptimized sequences. Importantly, our web-based tool has a user-friendly interface with flexible options to download results.

Availability and implementation

The web-based tool CoDe is freely available at https://web.iitm.ac.in/bioinfo2/codeop/landing_page.html.

Supplementary information

Supplementary data are available at Bioinformatics Advances online.

SUBMITTER: Sharma D

PROVIDER: S-EPMC9832946 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Publications

CoDe: a web-based tool for codon deoptimization.

Sharma Divya D Baas Tracey T Nogales Aitor A Martinez-Sobrido Luis L Gromiha M Michael MM

Bioinformatics advances 20230102 1

<h4>Summary</h4>We have developed a web-based tool, CoDe (Codon Deoptimization) that deoptimizes genetic sequences based on different codon usage bias, ultimately reducing expression of the corresponding protein. The tool could also deoptimize the sequence for a specific region and/or selected amino acid(s). Moreover, CoDe can highlight sites targeted by restriction enzymes in the wild-type and codon-deoptimized sequences. Importantly, our web-based tool has a user-friendly interface with flexib ...[more]

PMID: 36698765

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Dataset Information

CoDe: a web-based tool for codon deoptimization.

Summary

Availability and implementation

Supplementary information

Publications

CoDe: a web-based tool for codon deoptimization.

Similar Datasets

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