Dataset Information

Associations of body composition with incident dementia in older adults: Cardiovascular Health Study-Cognition Study.

ABSTRACT:

Introduction

A body of literature reported associations between late-life general adiposity measures (eg, body mass index) and dementia. Little is known about the association of late-life body composition with dementia risk.

Methods

We determined this association among cognitively normal participants from the Cardiovascular Health Study- Cognition Study. Body composition was assessed by dual-energy x-ray absorptiometry in 1994-1995. Dementia was ascertained at annual follow-up from 1998-1999 to 2013. Associations of body composition with incident dementia were assessed by the Fine-Gray model.

Result

Among 344 participants (mean age 78, 62.2% women), body composition was significantly different between men and women, despite similar body mass indexes (BMIs). Increased dementia risk was significantly associated with lower lean mass in men and marginally with low appendicular lean mass in women.

Discussion

Decreased lean mass was an indicator of increased dementia risk in older adults. Studies should test whether preventing lean mass loss in older adults reduces dementia risk.

SUBMITTER: Cui C

PROVIDER: S-EPMC7881417 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Publications

Associations of body composition with incident dementia in older adults: Cardiovascular Health Study-Cognition Study.

Cui Chendi C Mackey Rachel H RH Shaaban C Elizabeth CE Kuller Lewis H LH Lopez Oscar L OL Sekikawa Akira A

Alzheimer's & dementia : the journal of the Alzheimer's Association 20200817 10

<h4>Introduction</h4>A body of literature reported associations between late-life general adiposity measures (eg, body mass index) and dementia. Little is known about the association of late-life body composition with dementia risk.<h4>Methods</h4>We determined this association among cognitively normal participants from the Cardiovascular Health Study- Cognition Study. Body composition was assessed by dual-energy x-ray absorptiometry in 1994-1995. Dementia was ascertained at annual follow-up fro ...[more]

PMID: 32803916

Similar Datasets

Project description:OBJECTIVE:To examine associations of diet quality indicators with 4-year incidence of frailty in community-dwelling older adults. DESIGN:Prospective cohort study. SETTING:Health, Aging, and Body Composition Study, United States. PARTICIPANTS:Community-dwelling men and women, aged 70 to 81?years in 1998 to 1999 (first follow-up, present study's baseline; n?=?2154). MEASUREMENTS:At first follow-up, dietary intake over the preceding year was assessed with a food frequency questionnaire. Indicators of diet quality include the Healthy Eating Index (categorized as poor, medium, and good), energy intake, and protein intake (a priori adjusted for energy intake using the nutrient residual model). Frailty status was determined using Fried's five-component frailty phenotype and categorized into "robust" (0 components present), "pre-frailty" (1 - 2 components present), or "frail" (3-5 components present). Cox proportional hazards analysis was used to examine associations of the diet quality indicators with 4-year incidence of (1) frailty and (2) pre-frailty or frailty. Competing risk analysis was used to examine associations with frailty by accounting for competing risks of death. RESULTS:During the 4-year follow-up, 277 of the 2154 participants, robust or pre-frail at baseline, developed frailty, and 629 of the 1020 participants, robust at baseline, developed pre-frailty or frailty. Among the robust and pre-frail, after adjustment for confounders including energy intake, those consuming poor- and medium-quality diets had a higher frailty incidence than those consuming good-quality diets (hazard ratio [HR] = 1.92 [95% confidence interval {CI} = 1.17-3.17] and HR = 1.40 [95% CI = 0.99-1.98], respectively). No associations for energy or protein intake were observed. Competing risk analyses yielded similar results. Among the robust, those with lower vegetable protein intake had a higher "pre-frailty or frailty" incidence (per -10 g/d: HR = 1.20; 95% CI = 1.04-1.39). No other associations were observed. CONCLUSION:Poorer overall diet quality and lower vegetable protein intake may increase the risk of becoming frail in old age. We found no association for intakes of energy, total protein, or animal protein. J Am Geriatr Soc 67:1835-1842, 2019.

Dataset Information

Associations of body composition with incident dementia in older adults: Cardiovascular Health Study-Cognition Study.

Introduction

Methods

Result

Discussion

Publications

Associations of body composition with incident dementia in older adults: Cardiovascular Health Study-Cognition Study.

Similar Datasets

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