Selective vulnerability of inhibitory networks in multiple sclerosis.
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ABSTRACT:
SUBMITTER: Zoupi L
PROVIDER: S-EPMC7882577 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Publications
Selective vulnerability of inhibitory networks in multiple sclerosis.
Zoupi Lida L Booker Sam A SA Eigel Dimitri D Werner Carsten C Kind Peter C PC Spires-Jones Tara L TL Newland Ben B Williams Anna C AC
Acta neuropathologica 20210115 3
In multiple sclerosis (MS), a chronic demyelinating disease of the central nervous system, neurodegeneration is detected early in the disease course and is associated with the long-term disability of patients. Neurodegeneration is linked to both inflammation and demyelination, but its exact cause remains unknown. This gap in knowledge contributes to the current lack of treatments for the neurodegenerative phase of MS. Here we ask if neurodegeneration in MS affects specific neuronal components an ...[more]
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