Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC7882973 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Journal of cellular and molecular medicine 20201227 4
The migration of epidermal stem cells (EpSCs) is critical for wound re-epithelization and wound healing. Recently, growth/differentiation factor-5 (GDF-5) was discovered to have multiple biological effects on wound healing; however, its role in EpSCs remains unclear. In this work, recombinant mouse GDF-5 (rmGDF-5) was found via live imaging in vitro to facilitate the migration of mouse EpSCs in a wound-scratch model. Western blot and real-time PCR assays demonstrated that the expression levels o ...[more]