Ontology highlight
ABSTRACT:
SUBMITTER: Mangukiya HB
PROVIDER: S-EPMC6844563 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Cell adhesion & migration 20191201 1
The most prominent cancer-associated fibroblasts (CAFs) in tumor stroma is known to form a protective structure to support tumor growth. Anterior gradient-2 (AGR2), a tumor secretory protein is believed to play a pivotal role during tumor microenvironment (TME) development. Here, we report that extracellular AGR2 enhances fibroblasts elongation and migration significantly. The early stimulation of RhoA showed the association of AGR2 by upregulation of G1-S phase-regulatory protein cyclin D1 and ...[more]