Ontology highlight
ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC7883289 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Zhang Jing J Jiang Miaomiao M Zhao Hui H Han Lan L Jin Yu Y Chen Weidong W Wang Jianqing J Zhang Ziyu Z Peng Can C
Frontiers in pharmacology 20210201
Ischemic stroke is a common neurological disease that can lead to mortality and disability. The current curative effect remains unsatisfactory because drug accumulation in the diseased areas is insufficient as a result of the unique blood-brain barrier. Therefore, much attention has been paid to develop a novel therapeutic compound, paeonol-ozagrel conjugate (POC), for ischemic stroke. Then, POC was successfully synthesized by conjugating of paeonol and ozagrel as mutual prodrug. A series of <i> ...[more]