Ontology highlight
ABSTRACT:
SUBMITTER: Li X
PROVIDER: S-EPMC7883298 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
The EMBO journal 20210201 4
The ability of cells to polarize and move toward external stimuli plays a crucial role in development, as well as in normal and pathological physiology. Migrating cells maintain dynamic complementary distributions of Ras activity and of the phospholipid phosphatidylinositol-3,4-bisphosphate (PI(3,4)P2). Here, we show that lagging-edge component PI(3,4)P2 also localizes to retracting leading-edge protrusions and nascent macropinosomes, even in the absence of phosphatidylinositol 3,4,5-trisphospha ...[more]