Glycemic fluctuations caused by COVID-19: Results from continuous glucose monitoring.

ABSTRACT:

Aim

We aimed to address the potential impact of COVID-19 on glycemic patterns in a small pilot study.

Method

13 patients with mild COVID-19 who were confirmed without diabetes and another group of 18 healthy individuals with available CGM data were well matched and enrolled into the final analysis.

Results

We noticed significantly higher TARs of >140 mg/dL (median 13.9% vs. 2.3%, P = 0.006), >160 mg/dL (median 4.7% vs. 0.0%, P = 0.011) and >180 mg/dL (median 1.9% vs. 0.0%, P = 0.007) among non-diabetic patients with COVID-19 than those among healthy individuals. There was no significant difference in TBR of <70 mg/dL or <54 mg/dL (all P > 0.1). Consequently, the TIR of 70 mg/dL to 140 mg/dL was significantly lower in non-diabetic patients with COVID-19 than that in healthy individuals (median 80.1% vs. 93.1%, P = 0.001). Significant postprandial glycemic fluctuations were observed among patients with COVID-19. There was a remarkable difference in CV in non-diabetic patients with COVID-19 compared to healthy individuals (median 25.6% vs. 15.7%, P < 0.001).

Conclusion

Significant higher glycemic fluctuation and exposure to hyperglycemia was associated with COVID-19 among previously normoglycemic individuals, characterized with potentially impaired glucose tolerance.

SUBMITTER: Shen Y 

PROVIDER: S-EPMC7884232 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature