Longitudinal deterioration of white-matter integrity: heterogeneity in the ageing population.
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ABSTRACT:
SUBMITTER: Poulakis K
PROVIDER: S-EPMC7884606 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Longitudinal deterioration of white-matter integrity: heterogeneity in the ageing population.
Poulakis Konstantinos K Reid Robert I RI Przybelski Scott A SA Knopman David S DS Graff-Radford Jonathan J Lowe Val J VJ Mielke Michelle M MM Machulda Mary M MM Jack Clifford R CR Petersen Ronald C RC Westman Eric E Vemuri Prashanthi P
Brain communications 20210122 1
Deterioration in white-matter health plays a role in cognitive ageing. Our goal was to discern heterogeneity of white-matter tract vulnerability in ageing using longitudinal imaging data (two to five imaging and cognitive assessments per participant) from a population-based sample of 553 elderly participants (age ≥60 years). We found that different clusters (healthy white matter, fast white-matter decliners and intermediate white-matter group) were heterogeneous in the spatial distribution of wh ...[more]
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