Ontology highlight
ABSTRACT:
SUBMITTER: Zhou HM
PROVIDER: S-EPMC7884707 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Zhou He-Ming HM Zhang Ji-Gang JG Zhang Xue X Li Qin Q
Signal transduction and targeted therapy 20210215 1
Cancer stem cells (CSCs) show a self-renewal capacity and differentiation potential that contribute to tumor progression and therapy resistance. However, the underlying processes are still unclear. Elucidation of the key hallmarks and resistance mechanisms of CSCs may help improve patient outcomes and reduce relapse by altering therapeutic regimens. Here, we reviewed the identification of CSCs, the intrinsic and extrinsic mechanisms of therapy resistance in CSCs, the signaling pathways of CSCs t ...[more]