Unknown

Dataset Information

0

Low Cycle Threshold Value in Xpert MTB/RIF Assay May Herald False Detection of Tuberculosis and Rifampicin Resistance: A Study of Two Cases.

ABSTRACT: We report 2 cases for whom Xpert MTB/RIF falsely signaled rifampicin-resistant tuberculosis, based on unusually low cycle threshold and 3 of 5 probes missing. Other mycobacterial tests were negative. Further optimization of the Xpert MTB/RIF algorithm is warranted.

SUBMITTER: Ngabonziza JCS 

PROVIDER: S-EPMC7885858 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Low Cycle Threshold Value in Xpert MTB/RIF Assay May Herald False Detection of Tuberculosis and Rifampicin Resistance: A Study of Two Cases.

Ngabonziza Jean Claude S JCS   Decroo Tom T   Maniliho Rodrigue R   Habimana Yves M YM   Van Deun Armand A   de Jong Bouke C BC  

Open forum infectious diseases 20210121 2

We report 2 cases for whom Xpert MTB/RIF falsely signaled rifampicin-resistant tuberculosis, based on unusually low cycle threshold and 3 of 5 probes missing. Other mycobacterial tests were negative. Further optimization of the Xpert MTB/RIF algorithm is warranted. ...[more]

Similar Datasets

Unknown Xpert MTB/RIF Ultra and Xpert MTB/RIF assays for extrapulmonary tuberculosis and rifampicin resistance in adults.
| S-EPMC8078545 | biostudies-literature
Unknown False detection of rifampicin resistance using Xpert<sup>®</sup> MTB/RIF Ultra assay due to an A451V mutation in <i>Mycobacterium tuberculosis</i>.
| S-EPMC8355037 | biostudies-literature
Unknown Detection of Mycobacterium tuberculosis and rifampicin resistance by Xpert® MTB/RIF assay among presumptive tuberculosis cases at Jimma University Medical Center, Southwest Ethiopia.
| S-EPMC8794184 | biostudies-literature
Unknown Frequency of MTB and rifampicin resistance MTB using Xpert-MTB/RIF assay among adult presumptive tuberculosis patients in Tigray, Northern Ethiopia: A cross sectional study.
| S-EPMC7641410 | biostudies-literature
Unknown Evaluation of the analytical performance of the Xpert MTB/RIF assay.
| S-EPMC2897495 | biostudies-literature
Unknown Screening for HIV-associated tuberculosis and rifampicin resistance before antiretroviral therapy using the Xpert MTB/RIF assay: a prospective study.
| S-EPMC3144215 | biostudies-literature
Unknown Scaling-up the Xpert MTB/RIF assay for the detection of tuberculosis and rifampicin resistance in India: An economic analysis.
| S-EPMC5589184 | biostudies-literature
Unknown False-positive rifampin resistant results with Xpert MTB/RIF version 4 assay in clinical samples with a low bacterial load.
| S-EPMC4841693 | biostudies-literature
Unknown Comparison of Xpert MTB/RIF Assay and GenoType MTBDRplus DNA Probes for Detection of Mutations Associated with Rifampicin Resistance in Mycobacterium tuberculosis.
| S-EPMC4824420 | biostudies-literature
Unknown Accuracy of Xpert MTB/RIF assay for the diagnosis of tuberculous pleural effusion.
| S-EPMC8761404 | biostudies-literature