Ontology highlight
ABSTRACT:
SUBMITTER: Jackson DR
PROVIDER: S-EPMC7886370 | biostudies-literature | 2016 Jan
REPOSITORIES: biostudies-literature
Jackson David R DR Tu Stephanie S SS Nguyen MyChi M Barajas Jesus F JF Schaub Andrew J AJ Krug Daniel D Pistorius Dominik D Luo Ray R Müller Rolf R Tsai Shiou-Chuan SC
ACS chemical biology 20151103 1
The incorporation of nonacetate starter units during type II polyketide biosynthesis helps diversify natural products. Currently, there are few enzymatic strategies for the incorporation of nonacetate starter units in type II polyketide synthase (PKS) pathways. Here we report the crystal structure of AuaEII, the anthranilate:CoA ligase responsible for the generation of anthraniloyl-CoA, which is used as a starter unit by a type II PKS in aurachin biosynthesis. We present structural and protein s ...[more]