Phenotypic covariance across the entire spectrum of relatedness for 86 billion pairs of individuals.

ABSTRACT: Attributing the similarity between individuals to genetic and non-genetic factors is central to genetic analyses. In this paper we use the genomic relationship ([Formula: see text]) among 417,060 individuals to investigate the phenotypic covariance between pairs of individuals for 32 traits across the spectrum of relatedness, from unrelated pairs through to identical twins. We find linear relationships between phenotypic covariance and [Formula: see text] that agree with the SNP-based heritability ([Formula: see text]) in unrelated pairs ([Formula: see text]), and with pedigree-estimated heritability in close relatives ([Formula: see text]). The covariance increases faster than [Formula: see text] in distant relatives ([Formula: see text]), and we attribute this to imperfect linkage disequ

SUBMITTER: Kemper KE 

PROVIDER: S-EPMC7886899 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature