Ontology highlight
ABSTRACT:
SUBMITTER: Katagiri N
PROVIDER: S-EPMC7887226 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Scientific reports 20210216 1
Erythropoietin (EPO) is a crucial hormone for erythropoiesis and produced by adult kidneys. Insufficient EPO production in chronic kidney disease (CKD) can cause renal anemia. Although hypoxia-inducible factors (HIFs) are known as a main regulator, the mechanisms of EPO production have not been fully elucidated. In this study, we aimed to examine the roles of retinoic acid (RA) in EPO production using EPO-producing cells derived from human induced pluripotent stem cells (hiPSC-EPO cells) that we ...[more]