Ontology highlight
ABSTRACT:
SUBMITTER: Tojo Y
PROVIDER: S-EPMC4524113 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Tojo Yutaka Y Sekine Hiroki H Hirano Ikuo I Pan Xiaoqing X Souma Tomokazu T Tsujita Tadayuki T Kawaguchi Shin-ichi S Takeda Norihiko N Takeda Kotaro K Fong Guo-Hua GH Dan Takashi T Ichinose Masakazu M Miyata Toshio T Yamamoto Masayuki M Suzuki Norio N
Molecular and cellular biology 20150526 15
Erythropoietin (Epo) is produced in the kidney and liver in a hypoxia-inducible manner via the activation of hypoxia-inducible transcription factors (HIFs) to maintain oxygen homeostasis. Accelerating Epo production in hepatocytes is one plausible therapeutic strategy for treating anemia caused by kidney diseases. To elucidate the regulatory mechanisms of hepatic Epo production, we analyzed mouse lines harboring liver-specific deletions of genes encoding HIF-prolyl-hydroxylase isoforms (PHD1, PH ...[more]