Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC7887261 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Liu Yanhong Y Xia Jun J McKay James J Tsavachidis Spiridon S Xiao Xiangjun X Spitz Margaret R MR Cheng Chao C Byun Jinyoung J Hong Wei W Li Yafang Y Zhu Dakai D Song Zhuoyi Z Rosenberg Susan M SM Scheurer Michael E ME Kheradmand Farrah F Pikielny Claudio W CW Lusk Christine M CM Schwartz Ann G AG Wistuba Ignacio I II Cho Michael H MH Silverman Edwin K EK Bailey-Wilson Joan J Pinney Susan M SM Anderson Marshall M Kupert Elena E Gaba Colette C Mandal Diptasri D You Ming M de Andrade Mariza M Yang Ping P Liloglou Triantafillos T Davies Michael P A MPA Lissowska Jolanta J Swiatkowska Beata B Zaridze David D Mukeria Anush A Janout Vladimir V Holcatova Ivana I Mates Dana D Stojsic Jelena J Scelo Ghislaine G Brennan Paul P Liu Geoffrey G Field John K JK Hung Rayjean J RJ Christiani David C DC Amos Christopher I CI
NPJ precision oncology 20210216 1
Recent studies suggest that rare variants exhibit stronger effect sizes and might play a crucial role in the etiology of lung cancers (LC). Whole exome plus targeted sequencing of germline DNA was performed on 1045 LC cases and 885 controls in the discovery set. To unveil the inherited causal variants, we focused on rare and predicted deleterious variants and small indels enriched in cases or controls. Promising candidates were further validated in a series of 26,803 LCs and 555,107 controls. Du ...[more]