Ontology highlight
ABSTRACT:
SUBMITTER: Sang J
PROVIDER: S-EPMC9558843 | biostudies-literature | 2022 Oct
REPOSITORIES: biostudies-literature
Sang Jian J Zhang Tongwu T Kim Jung J Li Mengying M Pesatori Angela C AC Consonni Dario D Song Lei L Liu Jia J Zhao Wei W Hoang Phuc H PH Campbell Dave S DS Feng James J D'Arcy Monica E ME Synnott Naoise N Chen Yingxi Y Wu Zeni Z Zhu Bin B Yang Xiaohong R XR Brown Kevin M KM Choi Jiyeon J Shi Jianxin J Landi Maria Teresa MT
Human molecular genetics 20221001 20
Although multiple common susceptibility loci for lung cancer (LC) have been identified by genome-wide association studies, they can explain only a small portion of heritability. The etiological contribution of rare deleterious variants (RDVs) to LC risk is not fully characterized and may account for part of the missing heritability. Here, we sequenced the whole exomes of 2777 participants from the Environment and Genetics in Lung cancer Etiology study, a homogenous population including 1461 LC c ...[more]