Ontology highlight
ABSTRACT:
SUBMITTER: Kurashima Y
PROVIDER: S-EPMC7887276 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Kurashima Yosuke Y Kigoshi Takaaki T Murasaki Sayuri S Arai Fujimi F Shimada Kaoru K Seki Natsumi N Kim Yun-Gi YG Hase Koji K Ohno Hiroshi H Kawano Kazuya K Ashida Hiroshi H Suzuki Toshihiko T Morimoto Masako M Saito Yukari Y Sasou Ai A Goda Yuki Y Yuki Yoshikazu Y Inagaki Yutaka Y Iijima Hideki H Suda Wataru W Hattori Masahira M Kiyono Hiroshi H
Nature communications 20210216 1
Increases in adhesive and invasive commensal bacteria, such as Escherichia coli, and subsequent disruption of the epithelial barrier is implicated in the pathogenesis of inflammatory bowel disease (IBD). However, the protective systems against such barrier disruption are not fully understood. Here, we show that secretion of luminal glycoprotein 2 (GP2) from pancreatic acinar cells is induced in a TNF-dependent manner in mice with chemically induced colitis. Fecal GP2 concentration is also increa ...[more]