Ontology highlight
ABSTRACT:
SUBMITTER: Liu H
PROVIDER: S-EPMC7887405 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
iScience 20210121 2
Interferon (IFN)-induced activation of the signal transducer and activator of transcription (STAT) family is an important event in antiviral immunity. Here, we show that the nonreceptor kinases c-Abl and Arg directly interact with STAT1 and potentiate the phosphorylation of STAT1 on Y701. c-Abl/Arg could mediate STAT1 phosphorylation independent of Janus kinases in the absence of IFNγ and potentiate IFNγ-mediated STAT1 phosphorylation. Moreover, STAT1 dimerization, nuclear translocation, and dow ...[more]