Ontology highlight
ABSTRACT:
SUBMITTER: Huang TH
PROVIDER: S-EPMC3703149 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Cancer cell 20130601 6
Epidermal growth factor receptor (EGFR) initiates a signaling cascade that leads to DNA synthesis and cell proliferation, but its role in regulating DNA replication licensing is unclear. Here, we show that activated EGFR phosphorylates the p56 isoform of Lyn, p56(Lyn), at Y32, which then phosphorylates MCM7, a licensing factor critical for DNA replication, at Y600 to increase its association with other minichromosome maintenance complex proteins, thereby promoting DNA synthesis complex assembly ...[more]