Dataset Information

Isolation of different fungi from the skin of patients with seborrheic dermatitis.

ABSTRACT:

Background and purpose

Seborrheic dermatitis (SD) is characterized by erythematous inflammatory patches that mostly appear in the sebaceous gland-rich skin areas. In addition to the key role of Malassezia species in SD, its contribution to other fungal microbiota has been recently addressed in the literature. Regarding this, the present study was conducted to identify and determine the fungal species associated with the incidence of SD.

Materials and methods

For the purpose of the study, fungal microbiome in scaling samples were collected from SD lesions and then analyzed based on the DNA sequencing of ITS regions.

Results

In addition to Malassezia, several fungal species were detected in the samples collected from the SD lesions. According to the results, 15.5%, 13.3%, and 6.7% of the isolates were identified as Candida parapsilosis, Cryptococcus albidus var. albidus/ Rhodotorula mucilaginosa, and Penicillium polonicum, respectively.

Conclusion

Based on the obtained results, C. parapsilosis was the most prevalent non-Malassezia species isolated from SD lesions. Our results provided basic information about a specific fungal population accounting for the incidence of SD.

SUBMITTER: Mahmoudi E

PROVIDER: S-EPMC7888523 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Publications

Isolation of different fungi from the skin of patients with seborrheic dermatitis.

Mahmoudi Elaheh E Rezaie Jahangir J

Current medical mycology 20200601 2

<h4>Background and purpose</h4>Seborrheic dermatitis (SD) is characterized by erythematous inflammatory patches that mostly appear in the sebaceous gland-rich skin areas. In addition to the key role of <i>Malassezia</i> species in SD, its contribution to other fungal microbiota has been recently addressed in the literature. Regarding this, the present study was conducted to identify and determine the fungal species associated with the incidence of SD.<h4>Materials and methods</h4>For the purpose ...[more]

PMID: 33628982

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Project description:BackgroundPathogenesis of seborrheic dermatitis involves lipid secretion by sebaceous glands, Malassezia colonization, and an inflammatory response with skin barrier disruption. Each of these pathways could be modulated by diet, obesity, and nutritional supplements. Current treatment options provide only temporary control of the condition; thus, it is essential to recognize modifiable lifestyle factors that may play a role in determining disease severity.ObjectiveThis study aimed to summarize published evidence on diet, nutritional supplements, alcohol, obesity, and micronutrients in patients with seborrheic dermatitis and to provide useful insights into areas of further research.MethodsA literature search of Scopus, PubMed, and MEDLINE (Ovid interface) for English language papers published between 1993 and 2023 was conducted on April 16, 2023. Case-control studies, cohort studies, and randomized controlled trials with 5 or more subjects conducted on adult participants (>14 years) were included, case reports, case series, and review papers were excluded due to insufficient level of evidence.ResultsA total of 13 studies, 8 case-control, 3 cross-sectional, and 2 randomized controlled trials, involving 13,906 patients were included. Seborrheic dermatitis was correlated with significantly increased copper, manganese, iron, calcium, and magnesium concentrations and significantly lower serum zinc and vitamin D and E concentrations. Adherence to the Western diet was associated with a higher risk for seborrheic dermatitis in female patients and an increased consumption of fruit was associated with a lower risk of seborrheic dermatitis in all patients. The prebiotic Triphala improved patient satisfaction and decreased scalp sebum levels over 8 weeks. Most studies find associations between regular alcohol use and seborrheic dermatitis, but the association between BMI and obesity on seborrheic dermatitis severity and prevalence is mixed.ConclusionsThis review sheds light on specific promising areas of research that require further study, including the need for interventional studies evaluating serum zinc, vitamin D, and vitamin E supplementation for seborrheic dermatitis. The negative consequences of a Western diet, alcohol use, obesity, and the benefits of fruit consumption are well known; however, to fully understand their specific relationships to seborrheic dermatitis, further cohort or interventional studies are needed.Trial registrationPROSPERO CRD42023417768; https://tinyurl.com/bdcta893.

Project description:BACKGROUND:Seborrheic dermatitis (SD) is a common, chronic, inflammatory skin disorder, yet few studies have reported its clinical characteristics, or addressed its effect on quality of life (QoL). This study assesses the clinical characteristics and QoL of SD patients in China. It also identifies the clinical, demographic and environmental factors that may influence QoL. METHODS:Three hundred twelve SD outpatients from 9 hospitals completed a survey. QoL was measured with the dermatology-specific instrument Skindex-29. We collected social demographic characteristics and disease severity, and conducted logistic regression to determine the factors associated with QoL impairment. RESULTS:67.3% of the patients were females. The mean Skindex-29 overall score was 33.97 (SD?=?20.55). The breakdown was 40.79 (SD?=?24.24) for emotions, 32.83 (SD?=?19.84) for symptoms and 28.3 (SD?=?23.24) for functioning. 48.1% had severe emotional problems. Logistic regression analysis showed that BMI less than 25 (OR?=?0.223; 95% CI: 0.072-0.692; P?=?0.009), skin disease-related hospitalization (OR?=?6.882; 95% CI:1.767-26.795; P?=?0.005), environmental PM 10 levels above 120??g/m3 (OR?=?3.386; 95% CI: 1.253-9.15; P?=?0.016) and severe disease conditions (OR?=?4.438; 95% CI:1.26-15.626; P?=?0.02) were risk factors for severe emotional impairment. Moreover, skin disease-related hospitalization (OR?=?6.057; 95% CI:1.351-27.149; P?=?0.019), environmental PM 10 levels between 70 and 120??g/m3 (OR?=?6.317; 94% CI: 1.704-23.42; P?=?0.006), moderate (OR?=?2.388; 95% CI: 1.272-4.487; P?=?0.007) and severe disease conditions (OR?=?5.732; 95% CI: 1.838-17.88; P?=?0.003) were each risk factors for overall severe impairment. CONCLUSION:In China, nearly half of SD patients had severely emotional problems. Disease severity, BMI, dermatologic hospitalization, and ambient PM 10 levels are each risk factors for QoL impairment in SD patients. These implications are alarming, and warrant public health attention in SD disease management.

Dataset Information

Isolation of different fungi from the skin of patients with seborrheic dermatitis.

Background and purpose

Materials and methods

Results

Conclusion

Publications

Isolation of different fungi from the skin of patients with seborrheic dermatitis.

Similar Datasets

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